Reaktion #61659

Reaktionsgleichung

5-acetyl-7-benzyloxy-3,4-dihydro-1H-quinolin-2-one

2,3-dichloro-5,6-dicyanobenzoquinone

→

5-acetyl-7-benzyloxy-1H-quinolin-2-one

Lösungsmittel

dioxane

Reaktionsbedingungen

Aufarbeitung

1. 1
   TemperaturThe mixture is refluxed for 30 minutes
2. 2
   FiltrationThe solid is filtered off
3. 3
   Waschenwashed with dioxane
4. 4
   workup.DISSOLUTIONdissolved in 600 mL dichloromethane/methanol (9:1)
5. 5
   WaschenThe solution is washed with sodium hydrogen carbonate solution
6. 6
   Trocknendried with sodium sulphate
7. 7
   Sonstigeevaporated down
8. 8
   Filtrationfiltered
9. 9
   Sonstigedried

Vorschrift

13.0 g (44 mmol) 5-acetyl-7-benzyloxy-3,4-dihydro-1H-quinolin-2-one are suspended in 130 mL dioxane and combined with 15.0 g (66 mmol) of 2,3-dichloro-5,6-dicyanobenzoquinone. The mixture is refluxed for 30 minutes, cooled to ambient temperature and stirred for a further 2 hours. The solid is filtered off, washed with dioxane and dissolved in 600 mL dichloromethane/methanol (9:1). The solution is washed with sodium hydrogen carbonate solution, dried with sodium sulphate and evaporated down. Then the residue is suspended in methanol, filtered and dried.

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