Reaktion #616569

Reaktionsgleichung

(R)-tert-butyl 3-((2,2,2-trifluoro-N-((1R,2S)-2-phenylcyclopropyl)acetamido)methyl)pyrrolidine-1-carboxylate

TFA

→

product

Ausbeute 98.1%

2,2,2-Trifluoro-N-((1R,2S)-2-phenylcyclopropyl)-N—((S)-pyrrolidin-3-ylmethyl)acetamide

Ausbeute 98.1%

Lösungsmittel

dichloromethane

Reaktionsbedingungen

Aufarbeitung

1. 1
   EinengenThe mixture was concentrated
2. 2
   workup.ADDITIONthe residue was treated with saturated NaHCO3 solution
3. 3
   Extraktionextracted with DCM (3×)
4. 4
   TrocknenThe extract was dried (Na2SO4)
5. 5
   Einengenconcentrated
6. 6
   SonstigeThe residue was dried under vacuum

Vorschrift

To a solution of (R)-tert-butyl 3-((2,2,2-trifluoro-N-((1R,2S)-2-phenylcyclopropyl)acetamido)methyl)pyrrolidine-1-carboxylate (1.28 g, 3.10 mmol) in dichloromethane (DCM) (12 mL) was added TFA (3 ml, 38.9 mmol), and the mixture was stirred at room temperature for 3 h. The mixture was concentrated and the residue was treated with saturated NaHCO3 solution and extracted with DCM (3×). The extract was dried (Na2SO4) and concentrated. The residue was dried under vacuum to give 950 mg of product as pale yellow oil.

Quelle