Reaktion #61654

Reaktionsgleichung

7-acetyl-5-benzyloxy-3H-benzoxazol-2-one

selenium dioxide

charcoal

dioxane

→

5-benzyloxy-7-(2-ethoxy-2-hydroxy-acetyl)-3H-benzoxazol-2-one

Lösungsmittel

water

Reaktionsbedingungen

Aufarbeitung

1. 1
   FiltrationThe solid is filtered off
2. 2
   workup.DISTILLATIONthe solvent is distilled off
3. 3
   TemperaturThe mixture is refluxed for 15 minutes
4. 4
   Filtrationfiltered through activated charcoal
5. 5
   SonstigeThe solid precipitated
6. 6
   Temperaturon cooling
7. 7
   Filtrationis suction filtered after 3 hours
8. 8
   Waschenwashed with ethanol and diethyl ether

Vorschrift

20 g (71 mmol) 7-acetyl-5-benzyloxy-3H-benzoxazol-2-one and 8 g (72 mmol) selenium dioxide are refluxed for 8 hours in the presence of activated charcoal in 100 mL dioxane and 3.1 mL water. The solid is filtered off, the solvent is distilled off and the residue is combined with 50 mL ethanol. The mixture is refluxed for 15 minutes and then filtered through activated charcoal. The solid precipitated on cooling is suction filtered after 3 hours and washed with ethanol and diethyl ether.

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