Reaktion #61644

Reaktionsgleichung

tert-butyl [3-methyl-3-(5-methyl-2-nitro-phenylamino)-butyl]-carbamate

→

tert-butyl [3-(2-amino-5-methyl-phenylamino)-3-methyl-butyl]-carbamate

Lösungsmittel

methanol

Reaktionsbedingungen

Aufarbeitung

1. 1
   SonstigeThen the catalyst is separated off
2. 2
   workup.DISTILLATIONthe solvent is distilled off

Vorschrift

4.71 g (14.0 mmol) tert-butyl [3-methyl-3-(5-methyl-2-nitro-phenylamino)-butyl]-carbamate are dissolved in 110 mL methanol and hydrogenated in the presence of 340 mg palladium on charcoal (10%) at ambient temperature. Then the catalyst is separated off and the solvent is distilled off. Brown solid. Yield: 3.72 g (87%); mass spectroscopy: [M+H]+=308.

Quelle