Reaktion #61643

Reaktionsgleichung

3-fluoro-4-nitro-toluene

tert-butyl (3-amino-3-methyl-butyl)-carbamate

potassium carbonate

→

tert-butyl [3-methyl-3-(5-methyl-2-nitro-phenylamino)-butyl]-carbamate

Lösungsmittel

DMF

Reaktionsbedingungen

Aufarbeitung

1. 1
   workup.DISTILLATIONThe solvent is distilled off
2. 2
   WaschenThe mixture is washed repeatedly with water
3. 3
   Trocknendried with sodium sulphate

Vorschrift

2.0 g (12.9 mmol) 3-fluoro-4-nitro-toluene, 2.6 g (13.0 mmol) tert-butyl (3-amino-3-methyl-butyl)-carbamate and 2.3 g (16.8 mmol) potassium carbonate are stirred overnight at ambient temperature in 20 mL DMF. The solvent is distilled off and the residue is combined with ethyl acetate. The mixture is washed repeatedly with water, dried with sodium sulphate and the solvent is eliminated. 4.8 g yellow oil. Mass spectroscopy: [M+H]+=338.

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