Reaktion #616254

ord-0f16b993c01745e283264e850836d300

Reaktionsgleichung

CCCCOC(=O)N1CCC2(C=Nc3ccc(CC(=O)OCC)cc32)CC1
butyl 5-(2-ethoxy-2-oxoethyl)spiro[indole-3,4′-piperidine]-1′-carboxylate
CC(C)(C)OC=O
H−Boc
→
CCOC(=O)Cc1ccc2c(c1)C1(CCN(C(=O)OC(C)(C)C)CC1)CN2
tert-butyl 5-(2-ethoxy-2-oxoethyl)spiro[indoline-3,4′-piperidine]-1′-carboxylate

Edukte

CCCCOC(=O)N1CCC2(C=Nc3ccc(CC(=O)OCC)cc32)CC1
butyl 5-(2-ethoxy-2-oxoethyl)spiro[indole-3,4′-piperidine]-1′-carboxylate
CC(C)(C)OC=O
H−Boc

Reagenzien

Keine

Reaktionsbedingungen

Detaillierte Bedingungen
See reaction.notes.procedure_details.

Vorschrift

tert-butyl 5-(2-ethoxy-2-oxoethyl)spiro[indoline-3,4′-piperidine]-1′-carboxylate was prepared by the procedures described in Example 1, Step 2, substituting tert-butyl 5-chlorospiro[indole-3,4′-piperidine]-1′-carboxylate with butyl 5-(2-ethoxy-2-oxoethyl)spiro[indole-3,4′-piperidine]-1′-carboxylate. LCMS (APCI+) m/z 275.2 [M+H−Boc]+; Rt=3.58 min.

Quelle

DOI: 10.6084/m9.figshare.5104873.v1Patent: US09346805B2uspto-grants-2016_05