Reaktion #616241

ord-2c1f45a56f584c0b9342b317165e1204

Reaktionsgleichung

CC(C)(C)OC(=O)N1CCC2(C=Nc3ccc(Br)cc32)CC1
tert-butyl 5-bromospiro[indole-3,4′-piperidine]-1′-carboxylate
CC(C)(C)OC=O
H−Boc
→
CC(C)(C)OC(=O)N1CCC2(CC1)CNc1ccc(Br)cc12
Tert-butyl 5-bromospiro[indoline-3,4′-piperidine]-1′-carboxylate

Edukte

CC(C)(C)OC(=O)N1CCC2(C=Nc3ccc(Br)cc32)CC1
tert-butyl 5-bromospiro[indole-3,4′-piperidine]-1′-carboxylate
CC(C)(C)OC=O
H−Boc

Reagenzien

Keine

Reaktionsbedingungen

Detaillierte Bedingungen
See reaction.notes.procedure_details.

Vorschrift

Tert-butyl 5-bromospiro[indoline-3,4′-piperidine]-1′-carboxylate was prepared by the procedures described in Example 1, Step 2, substituting tert-butyl 5-chlorospiro[indole-3,4′-piperidine]-1′-carboxylate with tert-butyl 5-bromospiro[indole-3,4′-piperidine]-1′-carboxylate. LCMS (APCI+) m/z 267, 269 [M+H−Boc]+; Rt=3.89 min.

Quelle

DOI: 10.6084/m9.figshare.5104873.v1Patent: US09346805B2uspto-grants-2016_05