Reaktion #61555

Reaktionsgleichung

1-[(5-Chloro-pyridin-2-ylcarbamoyl)-methyl]-4-(2,2,2-trifluoro-ethoxy)-1H-pyrazole-3,5-dicarboxylic acid diethyl ester

HCl

→

1-[(5-Chloro-pyridin-2-ylcarbamoyl)-methyl]4-(2,2,2-trifluoro-ethoxy)-1H-pyrazole-3,5-dicarboxylic acid 3-ethyl ester

Lösungsmittel

THF

NaOH

Reaktionsbedingungen

Aufarbeitung

1. 1
   FiltrationThe precipitating product was collected by filtration
2. 2
   Sonstigedried under reduced pressure

Vorschrift

To a solution of 400 mg 1-[(5-Chloro-pyridin-2-ylcarbamoyl)-methyl]-4-(2,2,2-trifluoro-ethoxy)-1H-pyrazole-3,5-dicarboxylic acid diethyl ester in 5 ml THF and 0.9 ml 1N NaOH were added. After standing for 16 h, the solution was acidified using 1 N HCl to pH 1. The precipitating product was collected by filtration and dried under reduced pressure. Yield: 142 mg.

Quelle