Reaktion #61547

Reaktionsgleichung

Diethyl Oxalacetate sodium salt

hydrazine monohydrochloride

→

5-Hydroxy-2H-pyrazole-3-carboxylic acid ethyl ester

Lösungsmittel

ethanol

water

HCl

Reaktionsbedingungen

Aufarbeitung

1. 1
   Extraktionextracted with DCM (3×100 ml)
2. 2
   TrocknenThe combined organic layers were dried over MgSO4
3. 3
   Filtrationfiltered
4. 4
   Einengenconcentrated under reduced pressure
5. 5
   SonstigeThe crude product was subjected to the next reaction step without further purification

Vorschrift

To a solution of 5 g Diethyl Oxalacetate sodium salt in 100 ml ethanol, 1.5 g hydrazine monohydrochloride were added and the reaction mixture was heated to 80° C. for 3 h. Then the solution was diluted with 100 ml of water containing 3 ml of halfconcentrated HCl and extracted with DCM (3×100 ml). The combined organic layers were dried over MgSO4, filtered and concentrated under reduced pressure. The crude product was subjected to the next reaction step without further purification; Yield: 3.4 g

Quelle