Reaktion #61479

Reaktionsgleichung

water

acetic anhydride

2,3,4,5-tetrahydro-1H-3-benzazepine

triethylamine

→

title compound

Ausbeute 95.0%

3-Acetyl-2,3,4,5-tetrahydro-1H-3-benzazepine

Ausbeute 95.0%

Lösungsmittel

dichloromethane

dichloromethane

Reaktionsbedingungen

Aufarbeitung

1. 1
   Sonstigethe organic layer separated
2. 2
   WaschenThe organic layer was washed with 0.5 M hydrochloric acid (50 ml), saturated sodium bicarbonate solution (50 ml), water (50 ml)
3. 3
   Trocknendried (Na2SO4)
4. 4
   SonstigeEvaporation of the solvent in vacuo

Vorschrift

A solution of acetic anhydride (6.37 g, 0.062 mol) in dichloromethane (50 ml) was added dropwise to a stirred solution of 2,3,4,5-tetrahydro-1H-3-benzazepine (8.35 g, 0.057 mol) and triethylamine (8.7 ml) in dichloromethane (50 ml) at 0° C. under argon. After stirring at room temperature for 18 h, water (80 ml) was added and the organic layer separated. The organic layer was washed with 0.5 M hydrochloric acid (50 ml), saturated sodium bicarbonate solution (50 ml), water (50 ml) and then dried (Na2SO4). Evaporation of the solvent in vacuo gave the title compound (10.24 g, 95%) as a yellow oil which solidified on standing.

Quelle