Reaktion #61478

Reaktionsgleichung

3-(tert-butyloxycarbonyl)-7-cyano-2,3,4,5-tetrahydro-1H-3-benzazepine

trifluoroacetic acid

→

title compound

Ausbeute 44.0%

7-Cyano-2,3,4,5-tetrahydro-1H-3-benzazepine

Ausbeute 44.0%

Lösungsmittel

dichloromethane

Reaktionsbedingungen

Aufarbeitung

1. 1
   SonstigeThe reaction mixture was evaporated to dryness in vacuo
2. 2
   Sonstigepartitioned between ethyl acetate (50 ml) and water (50 ml)
3. 3
   Extraktionre-extracted with ethyl acetate (2×30 ml)
4. 4
   TrocknenThe combined basic organic extracts were dried over sodium sulfate
5. 5
   Sonstigeevaporated in vacuo

Vorschrift

A mixture of 3-(tert-butyloxycarbonyl)-7-cyano-2,3,4,5-tetrahydro-1H-3-benzazepine (765 mg, 2.81 mmol) and trifluoroacetic acid (2 ml), in dichloromethane (20 ml) was stirred at 40° C. for 1 h. The reaction mixture was evaporated to dryness in vacuo and partitioned between ethyl acetate (50 ml) and water (50 ml). The aqueous layer was basified using potassium carbonate and re-extracted with ethyl acetate (2×30 ml). The combined basic organic extracts were dried over sodium sulfate and evaporated in vacuo to give the title compound as a colourless oil (212 mg, 44%).

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