Reaktion #61464

ord-f50bf29cfbad4dbb838aec172bf2ba31

Reaktionsgleichung

CS(=O)(=O)c1ccc(OCC2CC2)c(C(=O)O)c1
2-cyclopropylmethoxy-5-methanesulfonyl-benzoic acid
Cl.c1ccc2c(N3CCNCC3)nsc2c1
3-piperazin-1-yl-benzo[d]isothiazole hydrochloride
CCOC(C)=O
ethyl acetate
→
CS(=O)(=O)c1ccc(OCC2CC2)c(C(=O)N2CCN(c3nsc4ccccc34)CC2)c1
title compound
CS(=O)(=O)c1ccc(OCC2CC2)c(C(=O)N2CCN(c3nsc4ccccc34)CC2)c1
(4-Benzo[d]isothiazol-3-yl-piperazin-1-yl)-(2-cyclopropylmethoxy-5-methanesulfonyl-phenyl) -methanone

Edukte

CS(=O)(=O)c1ccc(OCC2CC2)c(C(=O)O)c1
2-cyclopropylmethoxy-5-methanesulfonyl-benzoic acid
Cl.c1ccc2c(N3CCNCC3)nsc2c1
3-piperazin-1-yl-benzo[d]isothiazole hydrochloride
CCOC(C)=O
ethyl acetate

Reagenzien

Keine

Lösungsmittel

CC#N
acetonitrile

Reaktionsbedingungen

Detaillierte Bedingungen
See reaction.notes.procedure_details.

Vorschrift

Prepared in analogy to example 1.1 b) from 2-cyclopropylmethoxy-5-methanesulfonyl-benzoic acid (Example 2.6) and 3-piperazin-1-yl-benzo[d]isothiazole hydrochloride (CA=87691-88-1) in acetonitrile. Chromatography (SiO2; ethyl acetate) yields the title compound as a colorless solid.

Quelle

DOI: 10.6084/m9.figshare.5104873.v1Patent: US07429585B2uspto-grants-2008_09