Reaktion #61462

ord-e0b778adcc6847c7860d7c0cb261a974

Reaktionsgleichung

CCN(CC)c1ccc(S(C)(=O)=O)cc1C(=O)O
2-diethylamino-5-methanesulfonyl-benzoic acid
Cl.c1ccc2c(N3CCNCC3)nsc2c1
3-piperazin-1-yl-benzo[d]isothiazole hydrochloride
CCOC(C)=O
ethyl acetate
→
CCN(CC)c1ccc(S(C)(=O)=O)cc1C(=O)N1CCN(c2nsc3ccccc23)CC1
title compound
CCN(CC)c1ccc(S(C)(=O)=O)cc1C(=O)N1CCN(c2nsc3ccccc23)CC1
(4-Benzo[d]isothiazol-3-yl-piperazin-1-yl)-(2-diethylamino-5-methanesulfonyl-phenyl) -methanone

Edukte

CCN(CC)c1ccc(S(C)(=O)=O)cc1C(=O)O
2-diethylamino-5-methanesulfonyl-benzoic acid
Cl.c1ccc2c(N3CCNCC3)nsc2c1
3-piperazin-1-yl-benzo[d]isothiazole hydrochloride
CCOC(C)=O
ethyl acetate

Reagenzien

Keine

Lösungsmittel

CC#N
acetonitrile

Reaktionsbedingungen

Detaillierte Bedingungen
See reaction.notes.procedure_details.

Vorschrift

Prepared in analogy to example 1.1 b) from 2-diethylamino-5-methanesulfonyl-benzoic acid (Example 2.5) and 3-piperazin-1-yl-benzo[d]isothiazole hydrochloride (CA=87691-88-1) in acetonitrile. Chromatography (SiO2; ethyl acetate) yields the title compound as a colorless solid. MS (m/e): 473.4 (M+H+; 100%)

Quelle

DOI: 10.6084/m9.figshare.5104873.v1Patent: US07429585B2uspto-grants-2008_09