Reaktion #61452

Reaktionsgleichung

2-chloroquinoxaline

piperazine-1-carboxylic acid tert-butyl ester

potassium carbonate

potassium iodide

→

4-Quinoxalin-2-yl-piperazine-1-carboxylic acid tert.-butyl Ester

Lösungsmittel

water

toluene

Reaktionsbedingungen

Aufarbeitung

1. 1
   Temperaturwas refluxed overnight
2. 2
   TemperaturThe reaction mixture was cooled
3. 3
   Extraktionextracted 3 times with ethyl acetate
4. 4
   SonstigeThe organic phase was dried
5. 5
   Sonstigeevaporated
6. 6
   Sonstigethe title compound was crystallised from methanol

Vorschrift

A mixture of 9.1 mmol 2-chloroquinoxaline, 10.0 mmol piperazine-1-carboxylic acid tert-butyl ester, 22.8 mmol potassium carbonate and 2.1 mmol potassium iodide in 20 ml of toluene was refluxed overnight. The reaction mixture was cooled, poured into water and extracted 3 times with ethyl acetate. The organic phase was dried, evaporated and the title compound was crystallised from methanol. Yellowish solid.

Quelle