Reaktion #61442

ord-5e408c73bec7415b80a7e75099e4665e

Reaktionsgleichung

Cc1nc2cc(N3CCNCC3)ccc2s1.Cl
2-methyl-5-piperazin-1-yl-benzothiazole hydrochloride
CC(C)COc1ccc(S(C)(=O)=O)cc1C(=O)O
2-isobutoxy-5-methanesulfonyl-benzoic acid
CCOC(C)=O
ethyl acetate
→
Cc1nc2cc(N3CCN(C(=O)c4cc(S(C)(=O)=O)ccc4OCC(C)C)CC3)ccc2s1
title compound
Cc1nc2cc(N3CCN(C(=O)c4cc(S(C)(=O)=O)ccc4OCC(C)C)CC3)ccc2s1
(2-Isobutoxy-5-methanesulfonyl-phenyl)-[4-(2-methyl-benzothiazol-5-yl)-piperazin-1-yl]-methanone

Edukte

Cc1nc2cc(N3CCNCC3)ccc2s1.Cl
2-methyl-5-piperazin-1-yl-benzothiazole hydrochloride
CC(C)COc1ccc(S(C)(=O)=O)cc1C(=O)O
2-isobutoxy-5-methanesulfonyl-benzoic acid
CCOC(C)=O
ethyl acetate

Reagenzien

Keine

Lösungsmittel

CC#N
acetonitrile

Reaktionsbedingungen

Detaillierte Bedingungen
See reaction.notes.procedure_details.

Vorschrift

Prepared in analogy to example 1.1(b) from 2-methyl-5-piperazin-1-yl-benzothiazole hydrochloride and 2-isobutoxy-5-methanesulfonyl-benzoic acid (example 2.4) in acetonitrile. Chromatography (SiO2; ethyl acetate) yields the title compound as a brownish solid.

Quelle

DOI: 10.6084/m9.figshare.5104873.v1Patent: US07429585B2uspto-grants-2008_09