Reaktion #614331

Reaktionsgleichung

ethylacetate

9b-amino-4b-hydroxy-7-isopropyl-4b,9b-dihydro-5-oxa-indeno[2,1-a]inden-10-one

triethylamine

butyryl chloride

→

title compound

Ausbeute 79.0%

Butyric acid 2-(2-butyrylamino-1,3-dioxo-indan-2-yl)-5-isopropyl-phenyl ester

Ausbeute 79.0%

Lösungsmittel

methylene chloride

Reaktionsbedingungen

Aufarbeitung

1. 1
   Waschenwashed with water several time
2. 2
   SonstigeThe organic layer was dried
3. 3
   Filtrationfiltered
4. 4
   Sonstigepurified

Vorschrift

A solution of 9b-amino-4b-hydroxy-7-isopropyl-4b,9b-dihydro-5-oxa-indeno[2,1-a]inden-10-one (0.20 g, 0.67 mmol) in anhydrous methylene chloride (10 ml) was added triethylamine (0.20 g, 2.01 mmol) and butyryl chloride (0.18 g, 1.69 mmol) at room temperature and then stirred for 3 hrs. The reaction mixture was diluted in ethylacetate, and washed with water several time. The organic layer was dried, filtered, and purified using silica gel column chromatography (ethylacetate:hexane=1:4 to 1:2) to afford the title compound (230 mg, 79%).

Quelle