Reaktion #61432

ord-4ab9aa2551a14e6084c107e56cd16f4e

Reaktionsgleichung

CC(C)Oc1ccc(S(C)(=O)=O)cc1C(=O)O
2-isopropoxy-5-methanesulfonyl-benzoic acid
COC(=O)c1cccc2sc(N3CCNCC3)nc12.Cl
2-Piperazin-1-yl-benzothiazole-4-carboxylic acid methyl ester hydrochloride
→
COC(=O)c1cccc2sc(N3CCN(C(=O)c4cc(S(C)(=O)=O)ccc4OC(C)C)CC3)nc12
title compound
COC(=O)c1cccc2sc(N3CCN(C(=O)c4cc(S(C)(=O)=O)ccc4OC(C)C)CC3)nc12
2-[4-(2-Isopropoxy-5-methanesulfonyl-benzoyl)-piperazin-1-yl]-benzothiazole-4-carboxylic acid methyl ester

Edukte

CC(C)Oc1ccc(S(C)(=O)=O)cc1C(=O)O
2-isopropoxy-5-methanesulfonyl-benzoic acid
COC(=O)c1cccc2sc(N3CCNCC3)nc12.Cl
2-Piperazin-1-yl-benzothiazole-4-carboxylic acid methyl ester hydrochloride

Reagenzien

Keine

Lösungsmittel

C1CCOC1
tetrahydrofuran

Reaktionsbedingungen

Detaillierte Bedingungen
See reaction.notes.procedure_details.

Aufarbeitung

  1. 1
    SonstigeThe crude material was purified by chromatography (SiO2, heptane/ethyl acetate)
  2. 2
    Sonstigethe residue was then triturated in ether

Vorschrift

Prepared in analogy to example 1.1 b) from 2-isopropoxy-5-methanesulfonyl-benzoic acid (Example 2.2) and 2-Piperazin-1-yl-benzothiazole-4-carboxylic acid methyl ester hydrochloride in tetrahydrofuran. The crude material was purified by chromatography (SiO2, heptane/ethyl acetate), and the residue was then triturated in ether to yield the title compound as a white solid.

Quelle

DOI: 10.6084/m9.figshare.5104873.v1Patent: US07429585B2uspto-grants-2008_09