Reaktion #61431

ord-887fdcd2d99e4ae2a03c6c00569ee949

Reaktionsgleichung

CC(C)Oc1ccc(S(C)(=O)=O)cc1C(=O)O
2-Isopropoxy-5-methanesulfonyl-benzoic acid
O=[N+]([O-])c1ccc2nc(N3CCNCC3)sc2c1
6-Nitro-2-piperazin-1-yl-benzothiazole
→
CC(C)Oc1ccc(S(C)(=O)=O)cc1C(=O)N1CCN(c2nc3ccc([N+](=O)[O-])cc3s2)CC1
title compound
CC(C)Oc1ccc(S(C)(=O)=O)cc1C(=O)N1CCN(c2nc3ccc([N+](=O)[O-])cc3s2)CC1
(2-Isopropoxy-5-methanesulfonyl-phenyl)-[4-(6-nitro-benzothiazol-2-yl)-piperazin-1-yl]-methanone

Edukte

CC(C)Oc1ccc(S(C)(=O)=O)cc1C(=O)O
2-Isopropoxy-5-methanesulfonyl-benzoic acid
O=[N+]([O-])c1ccc2nc(N3CCNCC3)sc2c1
6-Nitro-2-piperazin-1-yl-benzothiazole

Reagenzien

Keine

Lösungsmittel

C1CCOC1
tetrahydrofuran

Reaktionsbedingungen

Detaillierte Bedingungen
See reaction.notes.procedure_details.

Aufarbeitung

  1. 1
    SonstigeThe crude material was purified by chromatography (SiO2, heptane/ethyl acetate)
  2. 2
    Sonstigethe residue was then triturated in ether

Vorschrift

Prepared in analogy to example 1.1 b) from 2-Isopropoxy-5-methanesulfonyl-benzoic acid (Example 2.2) and 6-Nitro-2-piperazin-1-yl-benzothiazole in tetrahydrofuran. The crude material was purified by chromatography (SiO2, heptane/ethyl acetate), and the residue was then triturated in ether to yield the title compound as a yellow solid.

Quelle

DOI: 10.6084/m9.figshare.5104873.v1Patent: US07429585B2uspto-grants-2008_09