Reaktion #61367

ord-fe6fe9f925824fb6aea92d62733bbd4f

Reaktionsgleichung

Cl.Cl.Nc1c(F)c(N)c(F)c(F)c1F
dihydrochloride
O=[N+]([O-])c1ccc(NCCc2ccccn2)cc1
N-(4-nitrophenyl)-N-(2-pyrid-2-ylethyl)amine
→
Cl.Cl.Nc1ccc(NCCc2ccccn2)cc1
amine
Cl.Cl.Nc1ccc(NCCc2ccccn2)cc1
N-(2-pyrid-2-ylethyl)benzene-1,4-diamine dihydrochloride

Edukte

Cl.Cl.Nc1c(F)c(N)c(F)c(F)c1F
dihydrochloride
O=[N+]([O-])c1ccc(NCCc2ccccn2)cc1
N-(4-nitrophenyl)-N-(2-pyrid-2-ylethyl)amine

Reagenzien

CCO.O.[Cl-].[NH4+].[Zn]
zinc ammonium chloride water ethanol

Reaktionsbedingungen

Detaillierte Bedingungen
See reaction.notes.procedure_details.

Vorschrift

The N-(4-nitrophenyl)-N-(2-pyrid-2-ylethyl)amine (5) obtained above was reduced with a boiling zinc/ammonium chloride/water/ethanol mixture. The corresponding amine was isolated in dihydrochloride form.

Quelle

DOI: 10.6084/m9.figshare.5104873.v1Patent: US07429278B2uspto-grants-2008_09