Reaktion #61311

ord-2332f716a30042dfad44534e29d04ebd

Reaktionsgleichung

CC(=O)N1CC2CC(c3ccc(OCCOc4cc(F)ccc4Br)cc3)=C(C(=O)O)C(C1)N2C(=O)OC(C)(C)C(Cl)(Cl)Cl

3-Acetyl-7-{4-[2-(2-bromo-5-fluorophenoxy)ethoxy]phenyl}-3,9-diazabicyclo[3.3.1]non-6-ene-6,9-dicarboxylic acid 9-(2,2,2-trichloro-1,1-dimethyl-ethyl) ester

CCOC(=O)C1=C(c2ccc(OCCOc3cccc(F)c3Cl)cc2)CC2CN(C(C)=O)CC1N2C(=O)OC(C)(C)C(Cl)(Cl)Cl

bicyclononene

3-Acetyl-7-{4-[2-(2-chloro-fluorophenoxy)ethoxy]phenyl}-3,9-diazabicyclo[3.3.1]non-6-ene-6,9-dicarboxylic acid 6-ethyl ester 9-(2,2,2-trichloro-1,1-dimethylethyl) ester

NaOH

→

CC(=O)N1CC2CC(c3ccc(OCCOc4cc(F)ccc4Cl)cc3)=C(C(=O)O)C(C1)N2C(=O)OC(C)(C)C(Cl)(Cl)Cl

3-Acetyl-7-{4-[2-(2-chloro-5-fluorophenoxy)ethoxy]phenyl}-3,9-diazabicyclo-[3.3.1]non-6-ene-6,9-dicarboxylic acid 9-(2,2,2-trichloro-1,1-dimethylethyl) ester

Edukte

BN2

3-Acetyl-7-{4-[2-(2-bromo-5-fluorophenoxy)ethoxy]phenyl}-3,9-diazabicyclo[3.3.1]non-6-ene-6,9-dicarboxylic acid 9-(2,2,2-trichloro-1,1-dimethyl-ethyl) ester

bicyclononene

3-Acetyl-7-{4-[2-(2-chloro-fluorophenoxy)ethoxy]phenyl}-3,9-diazabicyclo[3.3.1]non-6-ene-6,9-dicarboxylic acid 6-ethyl ester 9-(2,2,2-trichloro-1,1-dimethylethyl) ester

NaOH

Reagenzien

Keine

Lösungsmittel

EtOH

Reaktionsbedingungen

Detaillierte Bedingungen

See reaction.notes.procedure_details.

Aufarbeitung

1
SonstigeThe crude title compound (1.90 g, 74%) was used ftther without purification

Vorschrift

As described for compound BN2, but from bicyclononene BM10 (2.82 g, 3.94 mmol), aq. 1M NaOH (30 mL) and EtOH (70 mL). The crude title compound (1.90 g, 74%) was used ftther without purification.

Quelle

DOI: 10.6084/m9.figshare.5104873.v1Patent: US07427613B2uspto-grants-2008_09