Reaktion #612134

Reaktionsgleichung

3-chloro-5-fluoro-4-(1-methyl-3,6-dihydro-2H-pyridin-4-yl)pyridine

tert-butyl carbamate

sodium tert-butoxide

BrettPhos

BrettPhos

→

tert-butyl (5-fluoro-1′-methyl-1′,2′,3′,6′-tetrahydro-[4,4′-bipyridin]-3-yl)carbamate

Reaktionsbedingungen

Aufarbeitung

1. 1
   Sonstigean degassed by vacuum/nitrogen cycles (×5)
2. 2
   workup.ADDITIONDry dioxane (10 mL) was added
3. 3
   Sonstigewas placed into a pre-heated block at 100° C.
4. 4
   TemperaturThe reaction mixture was cooled to ambient temperature
5. 5
   Sonstigequenched with saturated NH4Cl
6. 6
   WaschenThe cartridge was washed with EtOAc/saturated NH4Cl
7. 7
   Sonstigethe layers of the filtrate separated
8. 8
   ExtraktionThe aqueous layer was extracted with EtOAc (×3)
9. 9
   Waschenthe combined organic extracts were washed with brine (×1)
10. 10
    Trocknendried (MgSO4)
11. 11
    Filtrationfiltered
12. 12
    Einengenconcentrated in vacuo
13. 13
    SonstigeThe residue was purified by column chromatography (ISCO Companion, 40 g column, eluting with 0 to 10% MeOH/DCM, loaded in DCM)

Vorschrift

3-chloro-5-fluoro-4-(1-methyl-3,6-dihydro-2H-pyridin-4-yl)pyridine (377 mg, 1.663 mmol), tert-butyl carbamate (974.1 mg, 8.315 mmol), sodium tert-butoxide (815.1 mg, 8.481 mmol), BrettPhos pre-catalyst (66.25 mg, 0.08315 mmol) and BrettPhos (44.63 mg, 0.08315 mmol) were placed in a sealable tube an degassed by vacuum/nitrogen cycles (×5). Dry dioxane (10 mL) was added and the resulting mixture was placed into a pre-heated block at 100° C. and stirred at this temperature for 16 hours. Further portions of BrettPhos pre-catalyst (66.25 mg, 0.08315 mmol) and BrettPhos (44.63 mg, 0.08315 mmol) were added and the reaction heated at 100° C. for 8 hours. The reaction mixture was cooled to ambient temperature and quenched with saturated NH4Cl. The mixture was passed through a pre-wetted (EtOAc) celite cartridge (2.5 g). The cartridge was washed with EtOAc/saturated NH4Cl and the layers of the filtrate separated. The aqueous layer was extracted with EtOAc (×3) and the combined organic extracts were washed with brine (×1), dried (MgSO4), filtered and concentrated in vacuo. The residue was purified by column chromatography (ISCO Companion, 40 g column, eluting with 0 to 10% MeOH/DCM, loaded in DCM) to give tert-butyl (5-fluoro-1′-methyl-1′,2′,3′,6′-tetrahydro-[4,4′-bipyridin]-3-yl)carbamate. MS (ES+) 308.2.

Quelle