Reaktion #612084

Reaktionsgleichung

1-(2-chloro-5-nitro-4-pyridyl)-4-methyl-piperazine

methylamine

THF

→

N-methyl-4-(4-methylpiperazin-1-yl)-5-nitro-pyridin-2-amine

Ausbeute 93.0%

Reaktionsbedingungen

Aufarbeitung

1. 1
   SonstigeThe mixture was purified by chromatography on silica (Companion 12 g)
2. 2
   Wascheneluting with 0.5-15% MeOH

Vorschrift

1-(2-chloro-5-nitro-4-pyridyl)-4-methyl-piperazine (265.9 mg, 1.036 mmol) and methylamine 2M in THF (2.590 mL of 2 M, 5.180 mmol) were heated overnight in a sealed tube at 60° C. The mixture was purified by chromatography on silica (Companion 12 g) eluting with 0.5-15% MeOH:DCM, yielding N-methyl-4-(4-methylpiperazin-1-yl)-5-nitro-pyridin-2-amine (243 mg, 93%). MS (ES+) 252.1.

Quelle