Reaktion #61206

ord-b5540e30025645ddba03804710f0b6db

Reaktionsgleichung

CS(=O)(=O)Nc1cc(C(F)(F)F)c([N+](=O)[O-])cc1I
N-(2-iodo-4-nitro-5-trifluoromethyl-phenyl)-methanesulfonamide
C#CC(=C)C
2-methyl-1-buten-3-yne
→
C=C(C)c1cc2cc([N+](=O)[O-])c(C(F)(F)F)cc2n1S(C)(=O)=O
title compound
C=C(C)c1cc2cc([N+](=O)[O-])c(C(F)(F)F)cc2n1S(C)(=O)=O
2-Isopropenyl-1-methanesulfonyl-5-nitro-6-trifluoromethyl-1H-indole

Edukte

CS(=O)(=O)Nc1cc(C(F)(F)F)c([N+](=O)[O-])cc1I
N-(2-iodo-4-nitro-5-trifluoromethyl-phenyl)-methanesulfonamide
C#CC(=C)C
2-methyl-1-buten-3-yne

Reagenzien

Keine

Reaktionsbedingungen

Detaillierte Bedingungen
See reaction.notes.procedure_details.

Aufarbeitung

  1. 1
    SonstigeThis compound-was prepared

Vorschrift

This compound-was prepared using the general Sonagashira conditions as described in general Example C, starting from N-(2-iodo-4-nitro-5-trifluoromethyl-phenyl)-methanesulfonamide (9.0 g, 21.9 mmol) and 2-methyl-1-buten-3-yne (6.25 mL, 65.7 mmol) to yield the title compound as a reddish-brown solid.

Quelle

DOI: 10.6084/m9.figshare.5104873.v1Patent: US07427682B2uspto-grants-2008_09