Reaktion #61167

Reaktionsgleichung

5-cyano-furan-2-carbonyl chloride

4-methoxy-2-piperidin-1-yl-phenylamine

DIEA

→

title compound

Ausbeute 60.0%

5-Cyano-furan-2-carboxylic acid (4-methoxy-2-piperidin-1-yl-phenyl)-amide

Ausbeute 60.0%

Reaktionsbedingungen

Vorschrift

Using a procedure similar to Example 1, step (e), 5-cyano-furan-2-carbonyl chloride (66 mg, 0.43 mmol) was allowed to react with 4-methoxy-2-piperidin-1-yl-phenylamine (67 mg, 0.32 mmol, as prepared in the previous step) in the presence of DIEA (164 μL, 0.940 mmol) for 2 h to afford 62 mg (60%) of the title compound as a yellow solid. 1H-NMR (CDCl3; 400 MHz): δ 9.49 (br s, 1H) 8.35 (d, 1H, J=8.9 Hz), 7.27-7.22 (m, 1H), 6.76 (d, 1H, J=2.7 Hz), 6.71 (dd, 1H, J=2.8, 8.9 Hz), 3.81 (s, 3H), 2.85-2.83 (m, 4H), 1.84-1.78 (m, 4H), 1.66-1.65 (m, 2H); Mass spectrum (ESI, m/z): Calcd. for C18H19N3O3, 326.1 (M+H), found 326.1.

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