Reaktion #611333

ord-04aef6da902d45f9a3cafaacdad986c9

Reaktionsgleichung

COc1ccc(C2=NN(C3CCNCC3)C(=O)C2(C)C)cc1OC.Cl
5-(3,4-dimethoxyphenyl)-4,4-dimethyl-2-(piperidin-4-yl)-2,4-dihydro-3H-pyrazol-3-one hydrochloride
COc1ccc(C2=NN(C3CCNCC3)C(=O)C2(C)C)cc1OC.Cl
compound B1
COc1ccc(C2=NN(C3CCNCC3)C(=O)C2(C)C)cc1OC.Cl
5-(3,4-dimethoxyphenyl)-4,4-dimethyl-2-(piperidin-4-yl)-2,4-dihydro-3H-pyrazol-3-one hydrochloride
O=S(=O)(Cl)c1ccccc1C(F)(F)F
2-(trifluoromethyl)benzenesulfonyl chloride
→
COc1ccc(C2=NN(C3CCN(S(=O)(=O)c4ccccc4C(F)(F)F)CC3)C(=O)C2(C)C)cc1OC
title compound
COc1ccc(C2=NN(C3CCN(S(=O)(=O)c4ccccc4C(F)(F)F)CC3)C(=O)C2(C)C)cc1OC
5-(3,4-Dimethoxyphenyl)-4,4-dimethyl-2-(1-{[2-(trifluoromethyl)phenyl]sulfonyl}piperidin-4-yl)-2,4-dihydro-3H-pyrazol-3-one

Edukte

COc1ccc(C2=NN(C3CCNCC3)C(=O)C2(C)C)cc1OC.Cl
5-(3,4-dimethoxyphenyl)-4,4-dimethyl-2-(piperidin-4-yl)-2,4-dihydro-3H-pyrazol-3-one hydrochloride
COc1ccc(C2=NN(C3CCNCC3)C(=O)C2(C)C)cc1OC.Cl
compound B1
COc1ccc(C2=NN(C3CCNCC3)C(=O)C2(C)C)cc1OC.Cl
5-(3,4-dimethoxyphenyl)-4,4-dimethyl-2-(piperidin-4-yl)-2,4-dihydro-3H-pyrazol-3-one hydrochloride
O=S(=O)(Cl)c1ccccc1C(F)(F)F
2-(trifluoromethyl)benzenesulfonyl chloride

Reagenzien

Keine

Reaktionsbedingungen

Detaillierte Bedingungen
See reaction.notes.procedure_details.

Aufarbeitung

  1. 1
    SonstigeThe title compound is prepared analogously
  2. 2
    SonstigeThe crude product is purified by crystallization from methanol

Vorschrift

The title compound is prepared analogously as described for GP1 using 5-(3,4-dimethoxyphenyl)-4,4-dimethyl-2-(piperidin-4-yl)-2,4-dihydro-3H-pyrazol-3-one hydrochloride (compound B1*HCl) and 2-(trifluoromethyl)benzenesulfonyl chloride as starting compounds. The crude product is purified by crystallization from methanol to yield the title compound.

Quelle

DOI: 10.6084/m9.figshare.5104873.v1Patent: US09340522B2uspto-grants-2016_05