Reaktion #61079

Reaktionsgleichung

3,4-dimethoxybenzylamine

2-chloroethyl isocyanate

→

title compound

Ausbeute 89.0%

N-{[3,4-Bis(methyloxy)phenyl]methyl}-N′-(2-chloroethyl)urea

Ausbeute 89.0%

Lösungsmittel

THF

Reaktionsbedingungen

Aufarbeitung

1. 1
   workup.ADDITIONafter the addition
2. 2
   EinengenIt was concentrated
3. 3
   Sonstigethe residue was purified by flash chromatography (silica gel, cHex/EtOAc 1:1→7:3 EtOAc/NH3 (0.5 in MeOH))

Vorschrift

To a solution of 3,4-dimethoxybenzylamine (2 g, 12 mmol) in anh. THF (25 mL), at r.t., under N2, was added 2-chloroethyl isocyanate (1.02 mL, 1 eq). The reaction was complete after the addition. It was concentrated and the residue was purified by flash chromatography (silica gel, cHex/EtOAc 1:1→7:3 EtOAc/NH3 (0.5 in MeOH)) to give the title compound as a white solid (2.9 g, 89%).

Quelle