Reaktion #610739

Reaktionsgleichung

HCl

DBU

6-bromo-benzo[b]thiophene-2-carboxylic acid

ethyl acetate

→

product

Ausbeute 78.0%

6-Bromo-benzo[b]thiophene

Ausbeute 78.0%

Lösungsmittel

DMA

hexane

Reaktionsbedingungen

Aufarbeitung

1. 1
   Extraktionextracted with ethyl acetate
2. 2
   EinengenThe organic layer was concentrated
3. 3
   Sonstigepurified by column chromatography on silica gel (100% hexane)

Vorschrift

DBU (1.21 g, 8.00 mmol) was added to a stirred solution of 6-bromo-benzo[b]thiophene-2-carboxylic acid (I-25b: 2.4 g, 8.85 mmol) in DMA (4 mL) at room temperature and the resulting mixture was heated in microwave at 200° C. for 1 hour. The reaction was monitored by TLC (50% ethyl acetate in hexane). The reaction mixture was acidified with 1N HCl and extracted with ethyl acetate. The organic layer was concentrated and purified by column chromatography on silica gel (100% hexane) to afford 320 mg of the product (78% yield).

Quelle