Reaktion #610735

Reaktionsgleichung

5-bromo-3-methyl-benzo[b]thiophene

N-fluoro benzene sulfonimide

diisopropyl amine

n-butyl lithium

→

product

Ausbeute 22.3%

5-Bromo-2-fluoro-3-methyl-benzo[b]thiophene

Ausbeute 22.3%

Lösungsmittel

THF

Reaktionsbedingungen

Aufarbeitung

1. 1
   Sonstigeto afford crude product
2. 2
   SonstigePurification by column chromatography on silica gel (hexane)

Vorschrift

Using analogous reaction condition and workup as described in Example 20 above from the preparation of I-20a, 5-bromo-3-methyl-benzo[b]thiophene (I-24b: 500 mg, 2.192 mmol) in dry THF was reacted with N-fluoro benzene sulfonimide (1.2 g, 3.94 mmol), diisopropyl amine (266.2 mg, 2.6315 mmol), n-butyl lithium (1.3 mL, 2.6315 mmol) to afford crude product. Purification by column chromatography on silica gel (hexane) afforded 120 mg of the product (22% yield).

Quelle