Reaktion #610718

Reaktionsgleichung

1-(4-cyclopropylpyridin-3-yl)imidazolidin-2-one

4-bromo-2-methoxypyridine

trans-N,N′-dimethylcyclohexane-1,2-diamine

potassium phosphate

→

product

Ausbeute 52.4%

1-(4-cyclopropylpyridin-3-yl)-3-(2-methoxypyridin-4-yl)imidazolidin-2-one

Ausbeute 52.4%

Lösungsmittel

1,4-dioxane

Reaktionsbedingungen

Aufarbeitung

1. 1
   Sonstigereagents and reaction conditions
2. 2
   Sonstigeto afford the crude product
3. 3
   SonstigePurification by column chromatography on silica gel (1% methanol in CHCl3)

Vorschrift

Using analogous reagents and reaction conditions as described in Example 1 above, 1-(4-cyclopropylpyridin-3-yl)imidazolidin-2-one (I-1d: 100 mg, 0.492 mmol) was reacted with 4-bromo-2-methoxypyridine (111.1 mg, 0.591 mmol), 1,4-dioxane (5 mL), copper iodide (9.39 mg, 0.049 mmol), trans-N,N′-dimethylcyclohexane-1,2-diamine (6.98 mg, 0.049 mmol) and potassium phosphate (312.9 mg, 1.476 mmol) to afford the crude product. Purification by column chromatography on silica gel (1% methanol in CHCl3) afforded 80 mg of the product (52% yield).

Quelle