Reaktion #61070

Reaktionsgleichung

water CH2Cl2

3-bromo-pyrazole

triphenylmethyl chloride

Et3N

→

title compound

Ausbeute 64.0%

3-Bromo-1-(triphenylmethyl)-1H-pyrazole

Ausbeute 64.0%

Lösungsmittel

CH2Cl2

Reaktionsbedingungen

Aufarbeitung

1. 1
   SonstigeThe phases were separated
2. 2
   Extraktionthe aqueous layer was further extracted with CH2Cl2 (2×30 mL)
3. 3
   TrocknenThe combined organic extracts were dried over anh. Na2SO4
4. 4
   Filtrationthe solids were filtered
5. 5
   Sonstigethe solvent evaporated
6. 6
   SonstigeThe residue was purified by flash chromatography (silica gel, 100% CH2Cl2)

Vorschrift

To a solution of 3-bromo-pyrazole (2.0 g, 13.6 mmol) in anh. CH2Cl2 (40 mL), at r.t., under N2, were added triphenylmethyl chloride (4.17 g, 1.1 eq) and Et3N (2.1 mL, 1.1 eq). The reaction mixture was stirred at r.t. for 4 hr. It was poured into water/CH2Cl2. The phases were separated and the aqueous layer was further extracted with CH2Cl2 (2×30 mL). The combined organic extracts were dried over anh. Na2SO4, the solids were filtered and the solvent evaporated. The residue was purified by flash chromatography (silica gel, 100% CH2Cl2) to give the title compound as a white solid (3.39 g, 64%).

Quelle