Reaktion #610523

Reaktionsgleichung

Coumarin

n-hexylamine

DBU

→

coumarin monoamine

Reaktionsbedingungen

Aufarbeitung

1. 1
   workup.ADDITIONmixed in bulk
2. 2
   SonstigeThe mixture was reacted in an oven
3. 3
   SonstigeThe resultant crude mixture was separated by preparative Thin Layer Chromatography (TLC) (eluent: ethylacetate/n-hexane=1/4 (vol./vol.))

Vorschrift

Coumarin (0.3775 g, 2.583 mmol), 2.0 equimolar of n-hexylamine (0.5324 g, 5.261 mmol) and 0.1 equimolar of DBU (0.0418 g, 0.275 mmol) were added and mixed in bulk. The mixture was reacted in an oven and kept at 50° C. for 10 days. The resultant crude mixture was separated by preparative Thin Layer Chromatography (TLC) (eluent: ethylacetate/n-hexane=1/4 (vol./vol.)) to give corresponding coumarin monoamine (1:2) adduct (0.8287 g, 2.378 mmol, yield=92%).

Quelle