Reaktion #61041

ord-f6809d22cfe94f4f9408cf7f89b2a34e

Reaktionsgleichung

CS(=O)(=O)c1ccc(I)c(C(=O)N2CCN(c3ccc(C(F)(F)F)cc3)CC2)c1
(2-Iodo-5-methanesulfonyl-phenyl)-[4-(4-trifluoromethyl-phenyl)-piperazin-1-yl]-methanone
Cc1c[nH]cn1
4-Methyl-1H-imidazole
Cc1cn(-c2ccc(S(C)(=O)=O)cc2C(=O)N2CCN(c3ccc(C(F)(F)F)cc3)CC2)cn1
title compound
Ausbeute 32.0%
Cc1cn(-c2ccc(S(C)(=O)=O)cc2C(=O)N2CCN(c3ccc(C(F)(F)F)cc3)CC2)cn1
[5-Methanesulfonyl-2-(4-methyl-imidazol-1-yl)-phenyl]-[4-(4-trifluoromethyl-phenyl)-piperazin-1-yl]-methanone
Ausbeute 32.0%

Reaktionsbedingungen

Detaillierte Bedingungen
See reaction.notes.procedure_details.

Vorschrift

The title compound was prepared according to the procedure described for example 199 from (2-Iodo-5-methanesulfonyl-phenyl)-[4-(4-trifluoromethyl-phenyl)-piperazin-1-yl]-methanone (compound CK) and 4-Methyl-1H-imidazole (32% yield, white solid, MS (m/e): 493.4 (M+H, 100%)

Quelle

DOI: 10.6084/m9.figshare.5104873.v1Patent: US07427612B2uspto-grants-2008_09