Reaktion #61037

ord-7409c338db0c4bf2b0cbc010faa42f10

Reaktionsgleichung

CS(=O)(=O)c1ccc(I)c(C(=O)O)c1
2-Iodo-5-methanesulfonyl-benzoic acid
CS(=O)(=O)c1ccc(N2CCNCC2)c(F)c1
1-(2-Fluoro-4-methanesulfonyl-phenyl)-piperazine
→
CS(=O)(=O)c1ccc(N2CCN(C(=O)c3cc(S(C)(=O)=O)ccc3I)CC2)c(F)c1
[4-(2-Fluoro-4-methanesulfonyl-phenyl)-piperazin-1-yl]-(2-iodo-5-methanesulfonyl-phenyl)-methanone

Edukte

CS(=O)(=O)c1ccc(I)c(C(=O)O)c1
2-Iodo-5-methanesulfonyl-benzoic acid
CS(=O)(=O)c1ccc(N2CCNCC2)c(F)c1
1-(2-Fluoro-4-methanesulfonyl-phenyl)-piperazine

Reagenzien

Keine

Reaktionsbedingungen

Detaillierte Bedingungen
See reaction.notes.procedure_details.

Vorschrift

Example CM was prepared in analogy to Example 123 from 2-Iodo-5-methanesulfonyl-benzoic acid (example BQ) and 1-(2-Fluoro-4-methanesulfonyl-phenyl)-piperazine (commercial). MS (m/e): 567.0 (M+H+, 100%).

Quelle

DOI: 10.6084/m9.figshare.5104873.v1Patent: US07427612B2uspto-grants-2008_09