Reaktion #61030

ord-6458fd7737ef4433b51e6ef6cb0cde08

Reaktionsgleichung

CNS(=O)(=O)c1ccc(F)c(C(=O)N2CCN(c3ccc(C(F)(F)F)cc3)CC2)c1F
2,4-Difluoro-N-methyl-3-[4-(4-trifluoromethyl-phenyl)-piperazine-1-carbonyl]-benzenesulfonamide
C1COCCN1
morpholine
→
CNS(=O)(=O)c1ccc(N2CCOCC2)c(C(=O)N2CCN(c3ccc(C(F)(F)F)cc3)CC2)c1F
title compound
CNS(=O)(=O)c1ccc(N2CCOCC2)c(C(=O)N2CCN(c3ccc(C(F)(F)F)cc3)CC2)c1F
2-Fluoro-N-methyl-4-morpholin-4-yl-3-[4-(4-trifluoromethyl-phenyl)-piperazine-1-carbonyl]-benzenesulfonamide

Edukte

CNS(=O)(=O)c1ccc(F)c(C(=O)N2CCN(c3ccc(C(F)(F)F)cc3)CC2)c1F
2,4-Difluoro-N-methyl-3-[4-(4-trifluoromethyl-phenyl)-piperazine-1-carbonyl]-benzenesulfonamide
C1COCCN1
morpholine

Reagenzien

Keine

Reaktionsbedingungen

Detaillierte Bedingungen
See reaction.notes.procedure_details.

Aufarbeitung

  1. 1
    SonstigeThe title compound was prepared

Vorschrift

The title compound was prepared according to the procedure described for example 202 from 2,4-Difluoro-N-methyl-3-[4-(4-trifluoromethyl-phenyl)-piperazine-1-carbonyl]-benzenesulfonamide (example CD) and morpholine to yield the title compound as a colourless foam, MS (m/e): 529.3 (M+H, 100%).

Quelle

DOI: 10.6084/m9.figshare.5104873.v1Patent: US07427612B2uspto-grants-2008_09