Reaktion #610280

Reaktionsgleichung

6-bromo-2-methoxypyridin-3-amine

1,2-dimethyl-1H-imidazole

KOAc

→

title compound

Ausbeute 16.5%

6-(1,2-Dimethyl-1H-imidazol-5-yl)-2-methoxypyridin-3-amine

Ausbeute 16.5%

Lösungsmittel

DMA

Reaktionsbedingungen

Aufarbeitung

1. 1
   FiltrationThe reaction mixture was filtered
2. 2
   workup.ADDITIONdiluted with NaCl solution
3. 3
   Extraktionextracted with EtOAc
4. 4
   SonstigeThe organic layer was purified
5. 5
   Waschenby eluting through an SCX-2 column
6. 6
   Wascheneluting with 0-4% MeOH/EtOAc

Vorschrift

A suspension of 6-bromo-2-methoxypyridin-3-amine (96 mg, 0.473 mmol), 1,2-dimethyl-1H-imidazole (91 mg, 0.946 mmol), Pd(OAc)2 (4.3 mg, 0.019 mmol), KOAc (93 mg, 0.95 mmol) in DMA (3 mL) was stirred at 1500 under microwave irradiation for 8 hours. The reaction mixture was filtered, diluted with NaCl solution and extracted with EtOAc. The organic layer was purified by eluting through an SCX-2 column using 2M NH3/MeOH followed by Biotage silica gel column chromatography eluting with 0-4% MeOH/EtOAc to give the title compound as pink solid (17 mg, 16%).

Quelle