Reaktion #60998

ord-d7c5da90161242f79b23e8662fcf8d54

Reaktionsgleichung

O=C(Cl)c1cc(Br)ccc1N1CCOCC1
5-Bromo-2-morpholin-4-yl-benzoyl chloride
CC(=O)c1ccc(N2CCNCC2)c(F)c1
1-(3-Fluoro-4-piperazin-1-yl-phenyl)-ethanone
→
CC(=O)c1ccc(N2CCN(C(=O)c3cc(Br)ccc3N3CCOCC3)CC2)c(F)c1
title compound
CC(=O)c1ccc(N2CCN(C(=O)c3cc(Br)ccc3N3CCOCC3)CC2)c(F)c1
1-{4-[4-(5-Bromo-2-morpholin-4-yl-benzoyl)-piperazin-1-yl]-3-fluoro-phenyl}-ethanone

Edukte

O=C(Cl)c1cc(Br)ccc1N1CCOCC1
5-Bromo-2-morpholin-4-yl-benzoyl chloride
CC(=O)c1ccc(N2CCNCC2)c(F)c1
1-(3-Fluoro-4-piperazin-1-yl-phenyl)-ethanone

Reagenzien

Keine

Reaktionsbedingungen

Detaillierte Bedingungen
See reaction.notes.procedure_details.

Vorschrift

The title compound was prepared according to the procedure described for example 46 from 5-Bromo-2-morpholin-4-yl-benzoyl chloride and 1-(3-Fluoro-4-piperazin-1-yl-phenyl)-ethanone (94%, yellow foam, MS (m/e): 490.3 (M+, 100%)

Quelle

DOI: 10.6084/m9.figshare.5104873.v1Patent: US07427612B2uspto-grants-2008_09