Reaktion #60957

ord-a8c0e4b2b4cb4225b0741446d7242d22

Reaktionsgleichung

CS(=O)(=O)c1ccc(N2CCCC2)c(C(=O)O)c1
5-Methanesulfonyl-2-pyrrolidin-1-yl-benzoic acid
CC(C)S(=O)(=O)c1ccc(Cl)c(C(=O)O)c1
2-Chloro-5-(propane-2-sulfonyl)-benzoic acid
C1CCNC1
pyrrolidine
→
CC(C)S(=O)(=O)c1ccc(N2CCCC2)c(C(=O)O)c1
title compound
Ausbeute 72.0%
CC(C)S(=O)(=O)c1ccc(N2CCCC2)c(C(=O)O)c1
5-(Propane-2-sulfonyl)-2-pyrrolidin-1-yl-benzoic acid
Ausbeute 72.0%

Edukte

CS(=O)(=O)c1ccc(N2CCCC2)c(C(=O)O)c1
5-Methanesulfonyl-2-pyrrolidin-1-yl-benzoic acid
CC(C)S(=O)(=O)c1ccc(Cl)c(C(=O)O)c1
2-Chloro-5-(propane-2-sulfonyl)-benzoic acid
C1CCNC1
pyrrolidine

Reagenzien

Keine

Reaktionsbedingungen

Detaillierte Bedingungen
See reaction.notes.procedure_details.

Aufarbeitung

  1. 1
    Sonstigeobtained in 72% yield

Vorschrift

The title compound was synthesised according to the procedure described for the synthesis of 5-Methanesulfonyl-2-pyrrolidin-1-yl-benzoic acid from 2-Chloro-5-(propane-2-sulfonyl)-benzoic acid and pyrrolidine and obtained in 72% yield. MS (m/e): 296.2 (MH−, 100%).

Quelle

DOI: 10.6084/m9.figshare.5104873.v1Patent: US07427612B2uspto-grants-2008_09