Reaktion #60939

ord-d5d5aa0a456a4044a6b254d0e42d7615

Reaktionsgleichung

CC(=O)c1ccc(N2CCNCC2)c(F)c1
1-(3-Fluoro-4-piperazin-1-yl-phenyl)-ethanone
N#Cc1ccc(Br)c(C(=O)O)c1
2-bromo-5-cyano-benzoic acid
→
CC(=O)c1ccc(N2CCN(C(=O)c3cc(C#N)ccc3Br)CC2)c(F)c1
Title compound
Ausbeute 49.0%
CC(=O)c1ccc(N2CCN(C(=O)c3cc(C#N)ccc3Br)CC2)c(F)c1
3-[4-(4-acetyl-2-fluoro-phenyl)-piperazine-1-carbonyl]-4-bromo benzonitrile
Ausbeute 49.0%

Edukte

CC(=O)c1ccc(N2CCNCC2)c(F)c1
1-(3-Fluoro-4-piperazin-1-yl-phenyl)-ethanone
N#Cc1ccc(Br)c(C(=O)O)c1
2-bromo-5-cyano-benzoic acid

Reagenzien

Keine

Reaktionsbedingungen

Detaillierte Bedingungen
See reaction.notes.procedure_details.

Vorschrift

Title compound was prepared according to procedure described in example K/step2 from 1-(3-Fluoro-4-piperazin-1-yl-phenyl)-ethanone and 2-bromo-5-cyano-benzoic acid, (49% yield, white solid, MS (m/e): 430 (M+, 100%).

Quelle

DOI: 10.6084/m9.figshare.5104873.v1Patent: US07427612B2uspto-grants-2008_09