Reaktion #60936

Reaktionsgleichung

2-Morpholin-4-yl-5-nitro-benzoyl chloride

1-(2-Chloro-phenyl)-piperazine

NEt3

→

[4-(2-Chloro-phenyl)-piperazin-1-yl]-(2-morpholin-4-yl-5-nitro-phenyl)-methanone

Lösungsmittel

DCM

Reaktionsbedingungen

Aufarbeitung

1. 1
   SonstigeAfter evaporation of the volatiles the residue
2. 2
   Sonstigesubjected to preparative HPLC purification on reversed phase
3. 3
   Wascheneluting with an acetonitrile/water gradient
4. 4
   Sonstigeto yield
5. 5
   Sonstigeafter evaporation of the product fractions 23.2 mg (77%) of the title compound

Vorschrift

A mixture of 18.9 mg (0.07 mmol) 2-Morpholin-4-yl-5-nitro-benzoyl chloride, 16.5 mg (0.084 mmol) 1-(2-Chloro-phenyl)-piperazine and 34 ul (0.245 mmol) NEt3 in 2 ml DCM was stirred at room temperature for 16 h. After evaporation of the volatiles the residue was taken up in 2 ml CH3CN/MeOH/HCOOH 2/2/1 and subjected to preparative HPLC purification on reversed phase eluting with an acetonitrile/water gradient to yield after evaporation of the product fractions 23.2 mg (77%) of the title compound. MS (m/e): 431.2 (MH+, 100%)

Quelle