Reaktion #60888

Reaktionsgleichung

5-(7-amino[1,3]thiazolo[5,4-d]pyrimidin-2-yl)-1-methyl-4-phenyl-1H-imidazole-2-thiol

5-(7-Amino[1,3]thiazolo[5,4-d]pyrimidin-2-yl)-1-methyl-4-phenyl-1H-imidazole-2-thiol

Intermediate 47

5-(7-Amino[1,3]thiazolo[5,4-d]pyrimidin-2-yl)-1-methyl-4-phenyl-1H-imidazole-2-thiol

N,N-diethyl-2-chloroethylamine hydrochloride

NaOH

→

title compound

2-(2-{[2-(Dimethylamino)ethyl]thio}-1-methyl-4-phenyl-1H-imidazol-5-yl)[1,3]thiazolo[5,4-d]pyrimidin-7-amine

Reaktionsbedingungen

Aufarbeitung

1. 1
   TemperaturAfter which the reaction mixture was cooled to ambient temperature

Vorschrift

A mixture of 5-(7-amino[1,3]thiazolo[5,4-d]pyrimidin-2-yl)-1-methyl-4-phenyl-1H-imidazole-2-thiol (Intermediate 47) (10 mg), N,N-diethyl-2-chloroethylamine hydrochloride (9 mg) and 2M NaOH (1 mL) was heated at 60° C. for 6 hours. After which the reaction mixture was cooled to ambient temperature and the title compound isolated by filtration as a yellow solid (6 mg, 50%);

Quelle