Reaktion #60880

Reaktionsgleichung

NaHCO3

6-Chloropyrimidine-4,5-diamine

Intermediate 88

6-Chloropyrimidine-4,5-diamine

HI

→

title compound

Ausbeute 98.0%

6-Iodopyrimidine-4,5-diamine

Ausbeute 98.0%

Reaktionsbedingungen

Aufarbeitung

1. 1
   workup.WAITat ambient temperature for 24 hours
2. 2
   ExtraktionThe product was extracted with EtOAc (3×15 mL)
3. 3
   TrocknenThe combined organics were dried (MgSO4)
4. 4
   Filtrationfiltered
5. 5
   Einengenconcentrated in vacuo

Vorschrift

6-Chloropyrimidine-4,5-diamine (Intermediate 88) (90 mg) was added slowly to HI (57%, aq) (2 mL) at 0° C. The reaction mixture was allowed to stir at 0° C. for 30 minutes and then at ambient temperature for 24 hours. NaHCO3 (sat aq.) was added dropwise until the reaction mixture was pH 8. The product was extracted with EtOAc (3×15 mL). The combined organics were dried (MgSO4), filtered and concentrated in vacuo to afford the title compound as a grey solid (144 mg, 98%);

Quelle