Reaktion #60870

Reaktionsgleichung

3-aminopyrrolidine

1-(cyclohexylmethyl)-4,5-diphenyl-1H-imidazole

7-(methylthio)[1,3]thiazolo[5,4-d]pyrimidine-2-carbaldehyde

Intermediate 77

7-(methylthio)[1,3]thiazolo[5,4-d]pyrimidine-2-carbaldehyde

Intermediate 73

4-aminothieno[2,3-d]pyrimidine-6-carbaldehyde

→

title compound

2-[1-(Cyclohexylmethyl)-4-phenyl-1H-imidazol-5-yl]-7-(methylthio)[1,3]thiazolo[5,4-d]pyrimidine

Reaktionsbedingungen

Aufarbeitung

1. 1
   Sonstigewas used in subsequent steps without further purification)

Vorschrift

The title compound was prepared by a similar process to that described for Example 65 but using 7-(methylthio)[1,3]thiazolo[5,4-d]pyrimidine-2-carbaldehyde (Intermediate 77) in place of 4-aminothieno[2,3-d]pyrimidine-6-carbaldehyde (Intermediate 73) and using cyclohexamethylamine in place of 3-aminopyrrolidine. Yellow solid (542 mg) (the product contained 33% of 1-(cyclohexylmethyl)-4,5-diphenyl-1H-imidazole but was used in subsequent steps without further purification);

Quelle