Reaktion #60790

Reaktionsgleichung

phosphoric acid

Phosphorous pentoxide

N-(4,6diaminopyrimidin-5-yl)-1-methyl-4-phenyl-1H-imidazole-5-carboxamide

intermediate 7

N-(4,6diaminopyrimidin-5-yl)-1-methyl-4-phenyl-1H-imidazole-5-carboxamide

NH3

→

title compound

Ausbeute 96.9%

8-(1-Methyl-4-phenyl-1H-imidazol-5-yl)-9H-purin-6-amine

Ausbeute 96.9%

Reaktionsbedingungen

Aufarbeitung

1. 1
   workup.ADDITIONIce was added to the cooled mixture, which
2. 2
   Filtrationthe resultant precipitate filtered off
3. 3
   Waschenwashed with water
4. 4
   Sonstigedried at 60° C. in vacuo

Vorschrift

Phosphorous pentoxide (1.06 g) was added to N-(4,6diaminopyrimidin-5-yl)-1-methyl-4-phenyl-1H-imidazole-5-carboxamide (intermediate 7) (171 mg) followed by phosphoric acid (85%, 0.76 mL) and heated at 160° C. for 72 hours. Ice was added to the cooled mixture, which was then adjusted to pH 5 with aqueous NH3, the resultant precipitate filtered off, washed with water and dried at 60° C. in vacuo to give the title compound as a cream solid (156 mg, 89%);

Quelle