Reaktion #60763

ord-bfdb7b1df3924e578a391468f3169498

Reaktionsgleichung

CC(C)(C)c1cc(NC(=O)Oc2ccccc2)no1
(5-t-butyl-isoxazol-3-yl)-carbamic acid phenyl ester
[N-]=C=O
isocyanate
NC1=c2ccoc2=NCN1c1cccc(N)c1
4-Amino-3-(3-aminophenyl)furo[2,3-d]pyrimidine
→
CC(C)(C)c1cc(NC(=O)Nc2cccc(N3CN=c4occc4=C3N)c2)no1
4-Amino-3-(3-((5-tert-butylisoxazol-3-yl)aminocarbonylamino)-phenyl)furo[2,3-d]pyrimidine

Edukte

—
diamine
CC(C)(C)c1cc(NC(=O)Oc2ccccc2)no1
(5-t-butyl-isoxazol-3-yl)-carbamic acid phenyl ester
[N-]=C=O
isocyanate
NC1=c2ccoc2=NCN1c1cccc(N)c1
4-Amino-3-(3-aminophenyl)furo[2,3-d]pyrimidine

Reagenzien

Keine

Reaktionsbedingungen

Detaillierte Bedingungen
See reaction.notes.procedure_details.

Aufarbeitung

  1. 1
    SonstigeThe compound was prepared

Vorschrift

The compound was prepared following the procedure described in Example 232(b), using (5-t-butyl-isoxazol-3-yl)-carbamic acid phenyl ester as the isocyanate of choice, and 4-Amino-3-(3-aminophenyl)furo[2,3-d]pyrimidine (10) as the diamine of choice. MS(ES) m/e 393 [M+H]+.

Quelle

DOI: 10.6084/m9.figshare.5104873.v1Patent: US07427623B2uspto-grants-2008_09