Reaktion #607443

Reaktionsgleichung

Vilsmeier reagent

5-bromo-6-(cis-4-isopropylcyclohexoxy)-2-methyl-pyridin-3-amine

dichloromethane

Vilsmeier reagent

phosphorus oxychloride

dichloromethane

→

title compound

Ausbeute 81.0%

N′-[5-bromo-6-(cis-4-isopropylcyclohexoxy)-2-methyl-3-pyridyl]-N-ethyl-N-methyl formamidine

Ausbeute 81.0%

Reaktionsbedingungen

Aufarbeitung

1. 1
   workup.ADDITIONAfter the addition
2. 2
   workup.STIRRINGStirring
3. 3
   workup.WAITwas continued for 1.5 h at room temperature
4. 4
   SonstigeThe reaction mixture was then quenched by the addition of water (100 mL)
5. 5
   workup.ADDITIONthe pH was adjusted to 14 by the addition of a 2.0 molar aqueous NaOH solution (80 mL)
6. 6
   SonstigeThe phases were separated
7. 7
   Extraktionthe aqueous phase extracted with dichloromethane (2×100 mL)
8. 8
   WaschenThe organic layer was washed with brine (250 mL)
9. 9
   Trocknendried over anhydrous Na2SO4
10. 10
    Filtrationfiltered
11. 11
    SonstigeThe solvent was removed in vacuo
12. 12
    Sonstigeto give a residue, which
13. 13
    Sonstigewas purified by column chromatography (silica gel, heptane/ethyl acetate, v/v=1/0-4/1)
14. 14
    workup.ADDITIONFractions containing the pure compound
15. 15
    Sonstigewere collected
16. 16
    Einengenconcentrated in vacuo

Vorschrift

The Vilsmeier reagent was freshly prepared by the slow addition of phosphorus oxychloride (7.09 mL, 75.89 mmol, 1.2 eq) to a solution of N,N-ethylmethylformamide (6.61 g, 75.89 mmol, 1.2 eq) in dichloromethane (75 mL) at room temperature. After the addition was complete, the reaction mixture was stirred at room temperature for 1 h. The Vilsmeier reagent was then added drop wise over 40 min to a solution of 5-bromo-6-(cis-4-isopropylcyclohexoxy)-2-methyl-pyridin-3-amine (20.70 g, 63.24 mmol) in dichloromethane (225 mL) at room temperature under inert atmosphere (Ar). Stirring was continued for 1.5 h at room temperature. The reaction mixture was then quenched by the addition of water (100 mL) and the pH was adjusted to 14 by the addition of a 2.0 molar aqueous NaOH solution (80 mL). The phases were separated and the aqueous phase extracted with dichloromethane (2×100 mL). The organic layer was washed with brine (250 mL), dried over anhydrous Na2SO4 and filtered. The solvent was removed in vacuo to give a residue, which was purified by column chromatography (silica gel, heptane/ethyl acetate, v/v=1/0-4/1). Fractions containing the pure compound were collected and concentrated in vacuo to give the title compound (20.23 g, 81%) as a yellow oil.

Quelle