Reaktion #607405

ord-3155e27bfa344f75b83b95e6e74eb016

Reaktionsgleichung

NC(CO)c1ccc(C(F)(F)F)cc1
2-amino-2-(4-(trifluoromethyl)phenyl)ethanol
FC(F)(F)Oc1ccc(-n2cnc(-c3ccc(N=C=S)cc3)n2)cc1
3-(4-isothiocyanato-phenyl)-1-(4-trifluoromethoxy-phenyl)-1H-1,2,4-triazole
OCC(NC(=S)Nc1ccc(-c2ncn(-c3ccc(OC(F)(F)F)cc3)n2)cc1)c1ccc(C(F)(F)F)cc1
title compound
OCC(NC(=S)Nc1ccc(-c2ncn(-c3ccc(OC(F)(F)F)cc3)n2)cc1)c1ccc(C(F)(F)F)cc1
1-(2-Hydroxy-1-(4-(trifluoromethyl)phenyl)ethyl)-3-(4-(1-(4-(trifluoromethoxy)phenyl)-1H-1,2,4-triazol-3-yl)phenyl)thiourea

Reaktionsbedingungen

Detaillierte Bedingungen
See reaction.notes.procedure_details.

Vorschrift

The title compound was prepared with 2-amino-2-(4-(trifluoromethyl)phenyl)ethanol and 3-(4-isothiocyanato-phenyl)-1-(4-trifluoromethoxy-phenyl)-1H-1,2,4-triazole and isolated as an off-white solid (0.250 g, 53%): ESIMS m/z 568 ([M+H]+).

Quelle

DOI: 10.6084/m9.figshare.5104873.v1Patent: US09326516B2uspto-grants-2016_05