Reaktion #60738

Reaktionsgleichung

1-(4-isopropylpiperazin-1-yl)-4-phenylbutane-1,4-dione 4-oxime

lithium aluminum hydride

→

title compound

Ausbeute 98.0%

4-(4-Isopropylpiperazin-1-yl)-1-phenyl-butylamine

Ausbeute 98.0%

Lösungsmittel

THF

Reaktionsbedingungen

Aufarbeitung

1. 1
   Temperaturwas cooled to 0 C
2. 2
   Sonstigethe reaction was quenched by slow addition of water and 1 N sodium hydroxide
3. 3
   FiltrationThe biphasic mixture was filtered through a pad of diatomaceous earth
4. 4
   Einengenthe filtered solution was concentrated to dryness

Vorschrift

To a solution of 1-(4-isopropylpiperazin-1-yl)-4-phenylbutane-1,4-dione 4-oxime (625 mg, 2.0 mmol) in 10 mL of THF was slowly added lithium aluminum hydride (250 mg, 6.6 mmol). The reaction flask was heated at 70° C. for 4 h after which time the flask was cooled to 0 C and the reaction was quenched by slow addition of water and 1 N sodium hydroxide. The biphasic mixture was filtered through a pad of diatomaceous earth, and the filtered solution was concentrated to dryness to afford 536 mg (98%) of the title compound as a crude residue that was used without further purification.

Quelle