Reaktion #60736

Reaktionsgleichung

4-oxo-4-phenylbutyric acid

hydroxylamine hydrochloride

sodium acetate

water

→

4-Hydroximino-4-phenylbutyric acid

Lösungsmittel

EtOH

Reaktionsbedingungen

Aufarbeitung

1. 1
   Temperaturwas then cooled to room temperature
2. 2
   Sonstigeafforded
3. 3
   Sonstigeafter recrystallization (10:1 chloroform:hexane), 620 mg (60%) of the title compound

Vorschrift

To a solution of 4-oxo-4-phenylbutyric acid (1.0 g, 5.3 mmol) in 50 mL of EtOH was added hydroxylamine hydrochloride (742 mg, 11 mmol) and sodium acetate (1.8 g, 21 mmol). The reaction flask was heated at 80° C. for 4 h and was then cooled to room temperature. Addition of water and filtration of the resultant precipitate afforded, after recrystallization (10:1 chloroform:hexane), 620 mg (60%) of the title compound.

Quelle