Reaktion #60711

ord-75c89a1f0fd449389cd5688723457621

Reaktionsgleichung

O=C(NC(COCC1CCNCC1)c1ccccc1F)c1ccc2c(Cl)c[nH]c2c1
3-chloro-N-[1-(2-fluoro-phenyl)-2-(piperidin-4-ylmethoxy)ethyl]-1H-indole-6-carboxamide
CC(C)=O
acetone
→
CC(C)N1CCC(COCC(NC(=O)c2ccc3c(Cl)c[nH]c3c2)c2ccccc2F)CC1
title compound
Ausbeute 78.0%
CC(C)N1CCC(COCC(NC(=O)c2ccc3c(Cl)c[nH]c3c2)c2ccccc2F)CC1
3-Chloro-N-[1-(2-fluorophenyl)-2-(1-isopropylpiperidin-4-yl-methoxy)ethyl]-1H-indole-6-carboxamide
Ausbeute 78.0%

Edukte

O=C(NC(COCC1CCNCC1)c1ccccc1F)c1ccc2c(Cl)c[nH]c2c1
3-chloro-N-[1-(2-fluoro-phenyl)-2-(piperidin-4-ylmethoxy)ethyl]-1H-indole-6-carboxamide
CC(C)=O
acetone

Reagenzien

Keine

Reaktionsbedingungen

Detaillierte Bedingungen
See reaction.notes.procedure_details.

Vorschrift

Using alkylation method A, 3-chloro-N-[1-(2-fluoro-phenyl)-2-(piperidin-4-ylmethoxy)ethyl]-1H-indole-6-carboxamide (303 mg, 0.71 mmol) and acetone (2 mL, 27 mmol) afforded 260 mg (78%) of the title compound.

Quelle

DOI: 10.6084/m9.figshare.5104873.v1Patent: US07427632B2uspto-grants-2008_09