Reaktion #60709

ord-e133d30be52b4d4f9e14ab88dbcb143c

Reaktionsgleichung

O=C(NC(COCC1CCNCC1)c1ccccc1Cl)c1cc2ccc(Cl)cc2s1
6-chloro-N-[1-(2-chloro-phenyl)-2-(piperidin-4-ylmethoxy)ethyl]benzo[b]thiophene-2-carboxamide
CC(C)=O
acetone
→
CC(C)N1CCC(COCC(NC(=O)c2cc3ccc(Cl)cc3s2)c2ccccc2Cl)CC1
6-Chloro-N-[1-(2-chlorophenyl)-2-(1-isopropylpiperidin-4-yl-methoxy)ethyl]benzo[b]thiophene-2-carboxamide

Edukte

O=C(NC(COCC1CCNCC1)c1ccccc1Cl)c1cc2ccc(Cl)cc2s1
6-chloro-N-[1-(2-chloro-phenyl)-2-(piperidin-4-ylmethoxy)ethyl]benzo[b]thiophene-2-carboxamide
CC(C)=O
acetone

Reagenzien

Keine

Reaktionsbedingungen

Detaillierte Bedingungen
See reaction.notes.procedure_details.

Aufarbeitung

  1. 1
    Sonstigeafforded
  2. 2
    Sonstigeafter purification (SiO2: 4:4:1 hexane EtOAc:isopropylamine), 150 mg (54%) of the title compound

Vorschrift

Using alkylation method A, 6-chloro-N-[1-(2-chloro-phenyl)-2-(piperidin-4-ylmethoxy)ethyl]benzo[b]thiophene-2-carboxamide (255 mg, 0.55 mmol) and acetone (2.0 mL, 27 mmol) afforded, after purification (SiO2: 4:4:1 hexane EtOAc:isopropylamine), 150 mg (54%) of the title compound.

Quelle

DOI: 10.6084/m9.figshare.5104873.v1Patent: US07427632B2uspto-grants-2008_09